Author

S. J. Langer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Organism:non-human primate· 1 Approach:statistical model· 1

Frequent Co-Authors

L. A. Leinwand· 3 shared A. Adhikari· 1 shared A. Combs· 1 shared A. Meller· 1 shared C. A. Johnson· 1 shared C. C. Ebmeier· 1 shared C. Crocini· 1 shared C. D. Vera· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiophysics

L. A. Leinwand

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3 papers

Recent·Most cited

A Conserved Mechanism of Cardiac Hypertrophy Regression through FoxO1

T. G. Martin, D. R. Hunt, S. J. Langer, Y. Tan, C. C. Ebmeier, C. Crocini, E. Chung, L. A. Leinwand

This study identifies FoxO1-dependent autophagy as a conserved mechanism for regression of physiological cardiac hypertrophy across species.

bioRxiv · Jan 27, 2024Physiology

Divergent Molecular Phenotypes in Point Mutations at the Same Residue in Beta-Myosin Heavy Chain Lead to Distinct Cardiomyopathies

S. J. Lehman, A. Meller, S. O. Solieva, J. M. Lotthammer, L. Greenberg, S. J. Langer, M. J. Greenberg, J. C. Tardiff, G. R. Bowman, L. A. Leinwand

This study shows that two point mutations at the same residue in beta-myosin heavy chain cause distinct cardiomyopathies through different molecular mechanisms.

bioRxiv · Jul 3, 2023 · PreprintBiophysics

Myosin motor domains carrying mutations implicated in early or late onset Hypertrophic Cardiomyopathy have similar properties

C. D. Vera, C. A. Johnson, J. Walklate, A. Adhikari, M. Svicevic, S. Mijailovich, A. Combs, S. J. Langer, K. M. Ruppel, J. A. Spudich, M. A. Geeves, L. A. LEINWAND

The paper analyzes myosin motor domain mutations in Hypertrophic Cardiomyopathy to compare early and late onset mutations, finding no clear functional differences but identifying distinct changes from DCM mutations.

bioRxiv · Aug 10, 2019Biophysics