L. Greenberg

Harnessing molecular mechanism for precision medicine in dilated cardiomyopathy caused by a mutation in troponin T

This study connects genotype, phenotype, and drug response in dilated cardiomyopathy using molecular mechanism-based computational and experimental approaches for a troponin T mutation.

Divergent Molecular Phenotypes in Point Mutations at the Same Residue in Beta-Myosin Heavy Chain Lead to Distinct Cardiomyopathies

This study shows that two point mutations at the same residue in beta-myosin heavy chain cause distinct cardiomyopathies through different molecular mechanisms.

Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains

This paper shows that the probability of cryptic pocket opening in myosin motor domains predicts drug specificity and affinity, using molecular dynamics simulations and Markov state models.

Sediment substrate size influences fish diversity in tributary mouth areas in impounded boreal rivers in Sweden

The study examines fish diversity in tributary mouth areas of impounded boreal rivers, finding that intermediate substrate sizes support higher diversity, while fine sediments reduce species richness.

Molecular basis of proteolytic cleavage regulation by the extracellular matrix receptor dystroglycan

This study identifies a unique mechanism by which dystroglycan is cleaved by MMPs, showing that structural changes disrupt DGC integrity and contribute to disease.

SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis

This study shows SARS-CoV-2 infects human engineered heart tissues, causing myocarditis-like features, and identifies ACE2 and proteases as entry factors.

Mechanical dysfunction induced by a hypertrophic cardiomyopathy mutation is the primary driver of cellular adaptation

This study shows that a HCM mutation causes mechanical dysfunction, which drives cellular adaptation through altered force generation and signaling pathways.

Disrupted mechanobiology links the molecular and cellular phenotypes in familial dilated cardiomyopathy

This study investigates how a mutation in troponin-T affects cellular contractility and mechanosensing in familial dilated cardiomyopathy.

Computational tool to study perturbations in muscle regulation and its application to heart disease

The paper introduces a computational tool to measure muscle activation equilibrium constants and analyze perturbations, applying it to study a mutation causing hypertrophic cardiomyopathy.