Author

S. J. Vos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:cell-cell communication· 1 Assay:flow cytometry· 1 Organism:human· 1

Frequent Co-Authors

D. Monroe· 4 shared D. Saul· 4 shared J. L. Rowsey· 4 shared J. N. Farr· 4 shared M. L. Doolittle· 4 shared S. Khosla· 4 shared J. Kaur· 2 shared R. L. Kosinsky· 2 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersPhysiology

D. Monroe

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Author profile →

4 papers

Recent·Most cited

Osteochondroprogenitor cells and neutrophils expressing p21 and senescence markers modulate fracture repair

D. Saul, M. L. Doolittle, J. L. Rowsey, M. N. Froemming, R. L. Kosinsky, S. J. Vos, M. Ruan, N. LeBrasseur, A. Chandra, R. Pignolo, J. Passos, J. N. Farr, D. Monroe, S. Khosla

This study identifies p21+ senescent-like cells, including osteochondroprogenitors and neutrophils, as key regulators of fracture repair, showing their distinct roles from age-related p16+ senescent cells.

bioRxiv · Feb 1, 2024Physiology

Multiparametric senescent cell phenotyping reveals CD24 osteolineage cells as targets of senolytic therapy in the aged murine skeleton

M. L. Doolittle, D. Saul, J. Kaur, J. L. Rowsey, S. J. Vos, K. D. Pavelko, J. N. Farr, D. Monroe, S. Khosla

The paper uses CyTOF to identify senescent mesenchymal cells in aged mice, finding CD24+ osteolineage cells as targets for senolytic therapy.

bioRxiv · Jan 12, 2023Cell Biology

Identification of a suitable endogenous control miRNA in bone aging and senescence

J. Kaur, D. Saul, M. L. Doolittle, J. L. Rowsey, S. J. Vos, J. N. Farr, S. Khosla, D. Monroe

The paper identifies Let-7f as a stable endogenous control miRNA for normalizing miRNA expression in bone aging and senescence, showing improved accuracy compared to U6.

bioRxiv · Feb 3, 2022Cell Biology

Modulation of fracture healing by the transient accumulation of senescent cells

S. Khosla, D. Saul, D. Monroe, J. L. Rowsey, R. L. Kosinsky, S. J. Vos, M. L. Doolittle, J. N. Farr

This study shows that senescent cells temporarily accumulate during murine fracture healing, and their removal with senolytics accelerates healing, unlike in skin wounds.

bioRxiv · May 18, 2021Physiology