R. L. Kosinsky

Osteochondroprogenitor cells and neutrophils expressing p21 and senescence markers modulate fracture repair

This study identifies p21+ senescent-like cells, including osteochondroprogenitors and neutrophils, as key regulators of fracture repair, showing their distinct roles from age-related p16+ senescent cells.

Distinct secretomes in p16- and p21- positive senescent cells across tissues

The paper examines p21Cip1 and p16Ink4a expression in senescent cells across tissues, revealing heterogeneity and tissue-specific SASP profiles.

Evolutionary analysis reveals the role of a non-catalytic domain of peptidyl arginine deiminase 2 in transcriptional regulation

The paper identifies positively selected residues in the non-catalytic domain of PADI2 and links them to transcriptional regulation and cellular proliferation.

A New Gene Set Identifies Senescent Cells and Predicts Senescence-Associated Pathways Across Tissues

This paper introduces a novel gene set, SenMayo, to identify senescent cells and predict senescence-associated pathways across tissues and species.

Modulation of fracture healing by the transient accumulation of senescent cells

This study shows that senescent cells temporarily accumulate during murine fracture healing, and their removal with senolytics accelerates healing, unlike in skin wounds.

Loss of Usp22 enhances histone H2B monoubiquitination and stimulates intracellular and systemic interferon immunity

The paper shows that loss of Usp22 increases H2Bub1 levels, leading to enhanced ISG expression and IFN immunity in mice.

RNF40-dependent epigenetic regulation of actin cytoskeletal dynamics is required for HER2-driven mammary tumorigenesis

This study identifies RNF40's role in HER2-positive breast cancer by showing its requirement for H2B monoubiquitination, which regulates actin dynamics and tumor growth.