Author

N. LeBrasseur

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Physiology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Organism:mouse· 5 Research Focus:cell-cell communication· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

D. Monroe· 4 shared D. Saul· 4 shared M. L. Doolittle· 4 shared D. Jurk· 3 shared J. Passos· 3 shared L. Niedernhofer· 3 shared R. L. Kosinsky· 3 shared R. Pignolo· 3 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersPhysiology

D. Monroe

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Osteochondroprogenitor cells and neutrophils expressing p21 and senescence markers modulate fracture repair

D. Saul, M. L. Doolittle, J. L. Rowsey, M. N. Froemming, R. L. Kosinsky, S. J. Vos, M. Ruan, N. LeBrasseur, A. Chandra, R. Pignolo, J. Passos, J. N. Farr, D. Monroe, S. Khosla

This study identifies p21+ senescent-like cells, including osteochondroprogenitors and neutrophils, as key regulators of fracture repair, showing their distinct roles from age-related p16+ senescent cells.

bioRxiv · Feb 1, 2024Physiology

Distinct secretomes in p16- and p21- positive senescent cells across tissues

D. Saul, D. Jurk, M. L. Doolittle, R. L. Kosinsky, D. Monroe, N. LeBrasseur, P. D. Robbins, L. Niedernhofer, M.D, S. Khosla, J. Passos

The paper examines p21Cip1 and p16Ink4a expression in senescent cells across tissues, revealing heterogeneity and tissue-specific SASP profiles.

bioRxiv · Dec 5, 2023 · PreprintCell Biology

In vitro and in vivo effects of zoledronate on senescence and senescence-associated secretory phenotype markers

P. Samakkarnthai, D. Saul, L. Zhang, Z. Aversa, M. L. Doolittle, J. Sfeir, J. Kaur, E. Atkinson, J. Edwards, G. Russell, R. Pignolo, J. Kirkland, T. Tchkonia, L. Niedernhofer, D. Monroe, , S. Khosla

This study shows zoledronate kills senescent cells in vitro and reduces SASP markers in vivo, suggesting potential senolytic and senomorphic effects.

Aging · May 7, 2023Peer-reviewedPhysiology

A New Gene Set Identifies Senescent Cells and Predicts Senescence-Associated Pathways Across Tissues

D. Saul, R. L. Kosinsky, E. J. Atkinson, M. L. Doolittle, X. Zhang, N. LeBrasseur, R. Pignolo, P. Robbins, L. Niedernhofer, Y. Ikeno, D. Jurk, J. Passos, L. Hickson, A. Xue, D. Monroe, , M.D, S. Khosla

This paper introduces a novel gene set, SenMayo, to identify senescent cells and predict senescence-associated pathways across tissues and species.

bioRxiv · Dec 10, 2021Cell Biology

Length-independent telomere damage drives cardiomyocyte senescence

R. Anderson, A. Lagnado, D. Maggiorani, A. Walaszczyk, E. Dookun, J. Chapman, J. Birch, H. Salmonowicz, M. Ogrodnik, D. Jurk, C. Proctor, C. Correia-Melo, S. Victorelli, E. Fielder, R. Berlinguer-Palmini, , J. F. Passos

This study shows that telomere damage independent of length causes cardiomyocyte senescence, leading to cardiac dysfunction, and that clearing senescent cells improves cardiac health.

bioRxiv · Aug 17, 2018Cell Biology