S. Khosla

Osteochondroprogenitor cells and neutrophils expressing p21 and senescence markers modulate fracture repair

This study identifies p21+ senescent-like cells, including osteochondroprogenitors and neutrophils, as key regulators of fracture repair, showing their distinct roles from age-related p16+ senescent cells.

Mycobacterium tuberculosis methyltransferase perturbs host epigenetic programming to promote bacterial survival

This study shows that Mtb methyltransferase Rv2067c modifies host histone H3K79 methylation, inhibiting apoptosis and enhancing necrosis to promote bacterial survival.

In vitro and in vivo effects of zoledronate on senescence and senescence-associated secretory phenotype markers

This study shows zoledronate kills senescent cells in vitro and reduces SASP markers in vivo, suggesting potential senolytic and senomorphic effects.

Multiparametric senescent cell phenotyping reveals CD24 osteolineage cells as targets of senolytic therapy in the aged murine skeleton

The paper uses CyTOF to identify senescent mesenchymal cells in aged mice, finding CD24+ osteolineage cells as targets for senolytic therapy.

DNA processing by the Kaposi's sarcoma-associated herpesvirus alkaline exonuclease SOX contributes to viral gene expression and infectious virion production

This study investigates the role of KSHV SOX, a bifunctional alkaline exonuclease, in viral DNA processing, gene expression, and virion production through structure-guided functional analysis.

Identification of a suitable endogenous control miRNA in bone aging and senescence

The paper identifies Let-7f as a stable endogenous control miRNA for normalizing miRNA expression in bone aging and senescence, showing improved accuracy compared to U6.

Modulation of fracture healing by the transient accumulation of senescent cells

This study shows that senescent cells temporarily accumulate during murine fracture healing, and their removal with senolytics accelerates healing, unlike in skin wounds.