Author

S. J. Zhang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 6 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:differential expression· 1 Organism:human· 1 Assay:proteomics· 1 Approach:simulation· 1

Frequent Co-Authors

J. W. Szostak· 7 shared D. Duzdevich· 2 shared S. DasGupta· 2 shared A. M. Egloff· 1 shared A. R. Parikh· 1 shared A. Wang· 1 shared B. D. Miller· 1 shared B. E. Johnson· 1 shared

Activity by Year

2020-2024 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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7 shared papersBiochemistry

J. W. Szostak

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Constraints on the Emergence of RNA through Non-Templated Primer Extension with Mixtures of Potentially Prebiotic Nucleotides

X. Jia, S. J. Zhang, L. Zhou, J. W. Szostak

This study investigates non-templated primer extension with alternative nucleotides to determine if RNA synthesis was biased against threo-nucleotides.

bioRxiv · Jan 21, 2024Biochemistry

Molecular crowding facilitates ribozyme-catalyzed RNA assembly

S. DasGupta, S. J. Zhang, J. W. Szostak

This study shows that molecular crowding supports ribozyme-catalyzed RNA assembly under low Mg2+ conditions, suggesting a role in early life.

bioRxiv · Apr 30, 2023Biochemistry

Enhanced nonenzymatic RNA copying with in-situ activation of short oligonucleotides

D. Ding, S. J. Zhang, J. W. Szostak

This study shows that eutectic phase phospho-Passerini chemistry activates short oligonucleotides, enabling efficient nonenzymatic template-directed RNA copying during freeze-thaw cycles.

bioRxiv · Apr 12, 2023 · PreprintBiochemistry

RNA-catalyzed RNA Ligation within Prebiotically Plausible Model Protocells

S. DasGupta, S. J. Zhang, M. P. Smela, J. W. Szostak

This study demonstrates RNA-catalyzed RNA ligation within fatty acid vesicles by using a ribozyme functional at low Mg2+ concentrations and prebiotically relevant molecules to stabilize the system.

bioRxiv · Feb 9, 2023Biochemistry

Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker

M. S. Taylor, W. Connie, P. C. Fridy, S. J. Zhang, Y. Senussi, J. C. Wolters, W.-C. Cheng, J. Heaps, B. D. Miller, K. Mori, L. Cohen, H. Jiang, K. R. Molloy, B. L. Norden, B. T. Chait, , O. H. Yilmaz

This study develops ultrasensitive assays to detect ORF1p in plasma, showing its potential as a multi-cancer biomarker for early detection and monitoring.

bioRxiv · Jan 25, 2023 · PreprintCancer Biology

Passive endocytosis in model protocells

S. J. Zhang, L. A. Lowe, P. Anees, Y. Krishnan, T. G. Fai, J. W. Szostak, A. Wang

This study shows that model protocells can perform a process similar to passive endocytosis, allowing rapid uptake and slow release of impermeable molecules, suggesting a possible mechanism for early nutrient acquisition before protein transporters evolved.

bioRxiv · Jan 7, 2023 · PreprintBiophysics

Freeze-thaw Cycles Enable a Prebiotically Plausible and Continuous Pathway from Nucleotide Activation to Nonenzymatic RNA Copying

S. J. Zhang, D. Duzdevich, C. E. Carr, J. W. Szostak

This paper demonstrates that freeze-thaw cycles enable a continuous prebiotic pathway for nucleotide activation and nonenzymatic RNA copying in a single reaction mixture.

bioRxiv · Sep 7, 2021Biochemistry

Prebiotically Plausible Activation Chemistry Compatible with Non-enzymatic RNA Copying

S. J. Zhang, D. Duzdevich, J. W. Szostak

This study presents a novel prebiotically plausible chemistry for activating RNA nucleotides, enabling nonenzymatic template-directed RNA copying.

bioRxiv · May 13, 2020 · PreprintBiochemistry