L. Cohen

Nf1 Deficiency Increases Mammary Collagen Deposition and Restricts Adipocyte Differentiation Before Tumor Formation

This study shows that Nf1 deficiency in rats increases mammary collagen and restricts adipocyte differentiation before tumor formation, suggesting a role in breast cancer risk.

Breast adipose tissue-derived extracellular vesicles from women with obesity stimulate mitochondrial-induced dysregulated tumor cell metabolism

This study shows that extracellular vesicles from obese women's breast adipose tissue promote mitochondrial metabolism and proliferation in ER+ breast cancer cells.

Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker

This study develops ultrasensitive assays to detect ORF1p in plasma, showing its potential as a multi-cancer biomarker for early detection and monitoring.

Spatiotemporal dynamics during niche remodeling by super-colonizing microbiota in the mammalian gut

This study investigates the spatiotemporal dynamics of microbial engraftment in the gut following fecal microbiota transplantation using a murine model.

MEK1/2 inhibition transiently alters the tumor immune microenvironment to enhance immunotherapy efficacy against head and neck cancer

This study shows that MEK1/2 inhibition temporarily improves the tumor immune microenvironment, enhancing immunotherapy effectiveness in head and neck cancer by reducing suppressive myeloid cells and boosting CD8+ T cell activity.

Lymphoid follicle formation and human vaccination responses recapitulated in an organ-on-a-chip

This paper demonstrates the formation of lymphoid follicles in a human organ-on-a-chip model and shows improved vaccine responses compared to 2D cultures.

TrackUSF, a novel methodology for automated analysis of ultrasonic vocalizations, reveals modified social communication in a rat model of autism

TrackUSF automates USV analysis, revealing altered social communication in Shank3-deficient rats.

The AP-1 complex regulates AXL expression and determines sensitivity to PI3Kα inhibition in esophagus and head and neck squamous cell carcinoma

This study shows that AP-1 factors regulate AXL expression, which contributes to resistance to PI3Kα inhibition in ESCC and HNSCC, and that JNK inhibition combined with PI3Kα inhibition enhances anti-tumor effects.