K. R. Molloy

This study develops ultrasensitive assays to detect ORF1p in plasma, showing its potential as a multi-cancer biomarker for early detection and monitoring.

This paper presents a large repertoire of high-affinity nanobodies against SARS-CoV-2 Spike protein with potent neutralization properties and resistance to viral variants.

This paper reconstitutes the human γ-TuRC and analyzes its structure and function, showing that the lumenal bridge is essential for microtubule nucleation.

This study maps the human nuclear cap-binding complex interactome using affinity proteomics to clarify the composition and interactions of NCBP1, NCBP2, and NCBP3-related macromolecular assemblies.

This study presents a cryo-EM structure of the native human γ-tubulin ring complex, revealing its asymmetric architecture and identifying new structural features and interactions.

The paper reports that ORF2p expression is undetectable in human cancers despite high ORF1p expression and somatic L1 retrotransposition.

The paper determines cryo-EM structures of the nucleolar large subunit processome in different states, revealing how assembly factors prevent premature folding and enable distinct folding pathways.

The paper presents the cryo-EM structure of the yeast small subunit processome, revealing its atomic model and mechanisms preventing premature pseudoknot formation.