O. H. Yilmaz

This paper shows 5-FU's lethality in tumors is due to an RNA damage response, not DNA damage, and that targeting this response could improve cancer therapy.

This study develops ultrasensitive assays to detect ORF1p in plasma, showing its potential as a multi-cancer biomarker for early detection and monitoring.

The paper combines single cell and spatial transcriptomics to map spatial organization and functional interactions in colorectal cancer across species.

This study shows that cancer tissue-of-origin influences the metabolism and growth preferences of both primary and metastatic tumors.

This study shows that ablative radiotherapy improves survival in autochthonous cancer mouse models and synergizes with androgen deprivation in prostate cancer.

This study identifies lymphatic endothelial cells (LECs) as a novel component of the intestinal stem cell (ISC) niche, alongside Rspo3+Grem1+ fibroblasts (RGFs), which together provide essential RSPO3 for ISC maintenance and regeneration.

This study shows that matrix stiffness affects intestinal stem cell fate by reducing Lgr5high ISCs and promoting differentiation into goblet cells, mediated by YAP nuclear translocation.

The paper shows that stem cell enlargement during aging reduces their function, and preventing this enlargement improves function.

The paper shows that a high fat diet reduces MHC-II expression in intestinal stem cells, promoting tumorigenesis by altering immune recognition.

The paper uses isotope tracing to compare metabolism between cancer cells and fibroblasts in pancreatic tumors, identifying key metabolic dependencies in cancer cells.