High-resolution profiling of neoantigen-specific T cell receptor activation signatures links moderate stimulation patterns to resilience and sustained tumor control
F. Füchsl, J. Untch, V. Kavaka, S. Jarosch, C. Vogelsang, N. de Andrade Krätzig, D. Gosmann, R. Rad, D. H. Busch, E. Beltran, E. Bräunlein, A. M. Krackhardt
The paper identifies and characterizes neoantigen-specific T cell receptors (neoTCRs) using single-cell sequencing and in vitro/in vivo experiments, finding that moderate activation profiles enhance tumor control.
bioRxiv · Sep 23, 2022 · PreprintImmunology