R. Rad

KRas, in addition to Tp53 is a driver for early carcinogenesis and a molecular target in a mouse model of invasive gastro-esophageal adenocarcinoma

This study identifies KRAS mutation as a driver of invasive gastro-esophageal adenocarcinoma in a mouse model, showing its synergistic role with Tp53 or Rb1 loss and potential as a therapeutic target.

RNF43 is a gatekeeper for colitis-associated cancer

This study identifies RNF43 mutations as a driver of colitis-associated cancer by showing their role in promoting inflammation and dysbiosis in mouse models and human patients.

Genomic and phenotypic stability of fusion-driven pediatric Ewing sarcoma cell lines

This study compares genomic and phenotypic stability of pediatric Ewing sarcoma cell lines to adult carcinoma cell lines over 12 months of culture.

eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content

The paper identifies eIF3k as a regulator of ribosome content in cancer by showing its depletion increases global translation and stress resistance through repression of RPS15A synthesis.

Functional synapses between small cell lung cancer and glutamatergic neurons

This study identifies glutamatergic synaptic interactions between SCLC cells and neurons, showing that these interactions support tumor growth and can be targeted therapeutically.

High-resolution profiling of neoantigen-specific T cell receptor activation signatures links moderate stimulation patterns to resilience and sustained tumor control

The paper identifies and characterizes neoantigen-specific T cell receptors (neoTCRs) using single-cell sequencing and in vitro/in vivo experiments, finding that moderate activation profiles enhance tumor control.

Proteogenomic analysis reveals RNA as an important source for tumor-agnostic neoantigen identification correlating with T-cell infiltration

This study identifies RNA as a significant source of tumor-agnostic neoantigens, which correlate with T-cell infiltration in multiple cancer types.

B/T cell crosstalk and aberrant inflammatory IgG exacerbate autoimmune intestinal inflammation

This study identifies B cell-driven inflammatory mechanisms, including aberrant IgG production and CD86-mediated T cell activation, as contributors to exacerbated intestinal inflammation in IBD.

Cancer tolerance to chromosomal instability is driven by Stat1 inactivation in vivo

The paper identifies Stat1 inactivation as a mechanism by which aneuploid cancers evade immune surveillance in mice and humans.

A GATA6-centered gene regulatory network involving HNFs and ΔNp63 controls plasticity and immune escape in pancreatic cancer

This paper identifies a GATA6-centered gene regulatory network involving HNFs and ΔNp63 that controls plasticity and immune escape in pancreatic cancer, showing GATA6 loss is necessary but not sufficient for the basal phenotype.

Spatial and temporal plasticity of neoantigen-specific T-cell responses bases on characteristics associated to antigen and TCR

The paper characterizes neoantigen-specific T-cell receptors in a melanoma patient, showing that low-avidity TCRs can provide effective anti-tumor responses and persist long-term in blood and tissues.

Targeting the ubiquitin-proteasome system in a pancreatic cancer subtype with hyperactive MYC

The paper identifies bortezomib as a potential therapy for MYC hyperactive pancreatic cancer by showing its sensitivity to proteasome inhibition.

Full-featured, real-time database searching platform enables fast and accurate multiplexed quantitative proteomics.

The paper introduces a real-time database search platform, Orbiter, that improves the efficiency and accuracy of multiplexed quantitative proteomics by reducing data acquisition time and increasing protein quantification.