Author

A. M. Krackhardt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 3 Organism:human· 3 Approach:deep learning· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

R. Rad· 3 shared D. Gosmann· 2 shared D. H. Busch· 2 shared E. Braeunlein· 2 shared F. Bassermann· 2 shared J. Untch· 2 shared K. Steiger· 2 shared M. Boxberg· 2 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersImmunology

R. Rad

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

High-resolution profiling of neoantigen-specific T cell receptor activation signatures links moderate stimulation patterns to resilience and sustained tumor control

F. Füchsl, J. Untch, V. Kavaka, S. Jarosch, C. Vogelsang, N. de Andrade Krätzig, D. Gosmann, R. Rad, D. H. Busch, E. Beltran, E. Bräunlein, A. M. Krackhardt

The paper identifies and characterizes neoantigen-specific T cell receptors (neoTCRs) using single-cell sequencing and in vitro/in vivo experiments, finding that moderate activation profiles enhance tumor control.

bioRxiv · Sep 23, 2022 · PreprintImmunology

Proteogenomic analysis reveals RNA as an important source for tumor-agnostic neoantigen identification correlating with T-cell infiltration

C. Tretter, N. de Andrade Kraetzig, M. Pecoraro, S. Lange, P. Seifert, C. von Frankenberg, J. Untch, F. S. Dreyer, E. Braeunlein, M. Wilhelm, D. P. Zolg, T. Engleitner, S. Uhrig, M. Boxberg, K. Steiger, , A. M. Krackhardt

This study identifies RNA as a significant source of tumor-agnostic neoantigens, which correlate with T-cell infiltration in multiple cancer types.

bioRxiv · Sep 17, 2022Cancer Biology

Spatial and temporal plasticity of neoantigen-specific T-cell responses bases on characteristics associated to antigen and TCR

E. Braeunlein, G. Lupoli, E. T. Abalrous, N. de Andrade Kraetzig, D. Gosmann, F. Fuechsl, L. Wietbrock, S. Lange, T. Engleitner, H. Lan, S. Audehm, M. Effenberger, M. Boxberg, K. Steiger, Y. Chang, , A. M. Krackhardt

The paper characterizes neoantigen-specific T-cell receptors in a melanoma patient, showing that low-avidity TCRs can provide effective anti-tumor responses and persist long-term in blood and tissues.

bioRxiv · Feb 2, 2021 · PreprintImmunology