Author

S. K. Gan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 2 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Assay:protein structure· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. Y. Yeo· 3 shared A. Wipat· 2 shared P. J. Bond· 2 shared W.-L. Ling· 2 shared A. Deacy· 1 shared A. Krah· 1 shared C. T. Su· 1 shared C. T. T. Su· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersImmunology

J. Y. Yeo

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

The Influence of Variable-Heavy (VH) Chain Families on IgG2, 3, 4 on FcγRs and Antibody Superantigens Protein G and L Binding using Biolayer Interferometry

A. Deacy, S. K. Gan

This study examines how variable-heavy (VH) chain families affect IgG2, 3, 4 binding to FcγRs and bacterial superantigens using biolayer interferometry, showing significant effects on receptor interactions but minimal impact on superantigen binding.

bioRxiv · Mar 26, 2023 · PreprintImmunology

The synergistic effects of the VH families and CH regions of multimeric IgM on its interaction with Fc(mu)R, and antigen.

W.-L. Ling, S. K. Gan

The paper investigates how the VH families and CH regions of IgM influence Fc(mu)R and antigen interactions through biolayer interferometry with engineered IgM variants.

bioRxiv · May 19, 2022 · PreprintImmunology

More than meets the Kappa for Antibody Superantigen Protein L (PpL)

W. L. Ling, J. Y. Yeo, Y. L. Ng, A. Wipat, S. K. Gan

The paper identifies novel PpL-antibody interactions beyond previously known specific regions, revealing broader binding contributions from VH-Vκ2, 5, and 6 regions.

bioRxiv · Nov 26, 2021Immunology

Engaging the A-Class Antibody: Variable-Heavy (VH) region influencing IgA1 engagement of FcαRI and superantigen proteins G, A, and L.

W.-L. Ling, C. T. Su, W.-H. Lua, J. Y. Yeo, J.-J. Poh, Y.-L. Ng, A. Wipat, S. K. Gan

This study investigates how the variable-heavy (VH) region of IgA1 and A2 influences FcαRI and superantigen protein binding, revealing structural and functional differences between subtypes.

bioRxiv · Sep 27, 2021 · PreprintImmunology

The Impact of Gag Non-Cleavage Site Mutations on HIV-1 Viral Fitness from Integrative Modelling and Simulations

F. Samsudin, S. K. Gan, P. J. Bond

This study uses multiscale modelling to show how Gag non-cleavage site mutations affect HIV-1 viral fitness by altering local environments and lipid interactions critical for Gag assembly and protease binding.

Computational and Structural Biotechnology Journal · Jan 1, 2021Peer-reviewedMicrobiology

An alternative HIV-1 non-nucleoside Reverse Transcriptase inhibition mechanism: Targeting the p51 subunit

K. F. Chan, C. T. T. Su, A. Krah, S. X. Phua, P. J. Bond, S. K. Gan

The paper identifies two chemical scaffolds that inhibit HIV-1 RT by binding to a novel site on the p51 subunit, suggesting a new class of non-nucleoside RT inhibitors.

bioRxiv · Jul 17, 2020 · PreprintMicrobiology

Method for Zero-Waste Circular Economy using worms for plastic agriculture: Augmenting polystyrene consumption and plant growth

S. K. Gan, S.-X. Phua, J. Y. Yeo, Z. S.-L. Heng, Z. Xing

This study shows mealworms and superworms can consume polystyrene and their frass can support plant growth, offering a zero-waste solution for plastic bioremediation and urban farming.

bioRxiv · May 29, 2020Ecology