F. Samsudin

Mapping the allosteric effects that define functional activity of SARS-CoV-2 specific antibodies

This study identifies site-specific allosteric effects in SARS-CoV-2 Spike protein induced by different neutralizing antibodies, revealing dynamic features that distinguish weak from strong neutralizers.

SARS-CoV-2 spike protein as a bacterial lipopolysaccharide delivery system in an overzealous inflammatory cascade

This study shows SARS-CoV-2 spike protein binds LPS, which may enhance immune activation via TLR4, with conserved binding sites across variants.

Spike independent infection of human coronavirus 229E in bat cells

This study shows that human coronavirus 229E can infect bat cells without using its spike protein, revealing a spike-independent infection mechanism in bats.

Uncovering cryptic pockets in the SARS-CoV-2 spike glycoprotein

This study identifies a novel cryptic pocket on the SARS-CoV-2 spike protein using molecular dynamics simulations and validates its druggable potential through experimental methods.

Site-specific steric control of SARS-CoV-2 spike glycosylation

The paper compares glycosylation patterns of recombinant SARS-CoV-2 spike proteins across labs with infectious virus S protein, finding conserved site-specific glycan maturation stalling linked to protein structure.

The Impact of Gag Non-Cleavage Site Mutations on HIV-1 Viral Fitness from Integrative Modelling and Simulations

This study uses multiscale modelling to show how Gag non-cleavage site mutations affect HIV-1 viral fitness by altering local environments and lipid interactions critical for Gag assembly and protease binding.

SARS-CoV-2 S protein ACE2 interaction reveals novel allosteric targets

The paper investigates how ACE2 binding to SARS-CoV-2 Spike protein allosterically affects proteolysis at distal cleavage sites and highlights potential therapeutic targets.

Interactions of a bacterial RND transporter with a transmembrane small protein in a lipid environment

The paper reports cryo-EM structures of AcrB and the AcrBZ complex, showing how AcrZ and lipid interactions modulate AcrB activity.

Pal stabilises the bacterial outer membrane during constriction by a mobilisation-and-capture mechanism

The paper shows the Tol system in E. coli actively mobilizes and captures Pal to coordinate outer membrane constriction with cell division.

The structural basis for distinct binding avidity of Pertuzumab and Trastuzumab IgM towards HER2

This paper investigates the structural basis for the differing binding avidity of Pertuzumab and Trastuzumab IgM to HER2, showing that Pertuzumab IgM binds more effectively due to stable engagement via all V-regions.

Binding From both sides: TolR and full-length OmpA bind and maintain the local structure of the E. coli cell wall

This study uses molecular modeling to show TolR and OmpA bind the E. coli cell wall from opposite sides, maintaining its structure without Brauns lipoprotein.