Author

J. Y. Yeo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cell Biology· 1 Ecology· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:proteomics· 7 Research Focus:cell type annotation· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Research Focus:protein folding & dynamics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

S. K. Gan· 3 shared S. K.-E. Gan· 3 shared A. Wipat· 2 shared J.-J. Poh· 2 shared W.-H. Lua· 2 shared W.-L. Ling· 2 shared A. Abokor· 1 shared A. M. Salazar· 1 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersImmunology

S. K. Gan

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Natural Killer cell contractility and cytotoxicity is driven by TLR3 agonist-mediated TAZ cytoplasmic sequestration

D. C. P. Wong, Z. Xia, N. Shao, J. Y. Yeo, T. Thivakar, I. Yow, A. M. Salazar, Y.-C. Liou, B. C. Low, J. L. Ding

This study shows that TLR3 agonist hiltonol sequesters TAZ in NK cells, enhancing cytotoxicity by increasing contractility and reducing inhibitory receptors.

bioRxiv · Jan 18, 2023 · PreprintCell Biology

More than meets the Kappa for Antibody Superantigen Protein L (PpL)

W. L. Ling, J. Y. Yeo, Y. L. Ng, A. Wipat, S. K. Gan

The paper identifies novel PpL-antibody interactions beyond previously known specific regions, revealing broader binding contributions from VH-Vκ2, 5, and 6 regions.

Antibodies · Feb 11, 2022Peer-reviewedImmunology

Engaging the A-Class Antibody: Variable-Heavy (VH) region influencing IgA1 engagement of FcαRI and superantigen proteins G, A, and L.

W.-L. Ling, C. T. Su, W.-H. Lua, J. Y. Yeo, J.-J. Poh, Y.-L. Ng, A. Wipat, S. K. Gan

This study investigates how the variable-heavy (VH) region of IgA1 and A2 influences FcαRI and superantigen protein binding, revealing structural and functional differences between subtypes.

bioRxiv · Sep 27, 2021 · PreprintImmunology

Spontaneous Mutations in HIV-1 Gag, protease, RT p66 in the first replication cycle and how they appear: Insights from an in vitro BSL2 assay on mutation rates and types.

J. Y. Yeo, D. W.-S. Koh, P. Yap, G.-R. Goh, S. K.-E. Gan

This study investigates mutation rates and types in HIV-1 Gag, protease, and RT p66 genes in an in vitro system, revealing host deaminase contributions to mutations.

bioRxiv · Jul 27, 2020Microbiology

Reconstitution of the host holobiont in germ-free rats acutely increases bone growth and affects marrow cellular content

P. J. Czernik, R. M. Golonka, S. Chakraborty, B. S. Yeoh, A. Abokor, P. Saha, J. Y. Yeo, B. Mell, X. Cheng, S. Baroi, B. Joe, M. Vijay-Kumar, B. Lecka-Czernik

This study shows that reconstituting the gut microbiota in germ-free rats accelerates bone growth and alters marrow cell composition, with effects linked to increased short-chain fatty acids and IGF-1 levels.

bioRxiv · Jul 15, 2020 · PreprintPhysiology

Molecular insight into Nickel(II) binding by Her2-specific IgE: a possible mechanistic insight into the pathogenesis of Type I nickel hypersensitivity

C. T.-T. Su, W.-H. Lua, J.-J. Poh, W.-L. Ling, J. Y. Yeo, S. K.-E. Gan

The paper investigates how Her2-specific IgE binds Nickel(II) and suggests this mechanism may explain Type I nickel hypersensitivity and its potential applications in therapeutics and biotechnology.

bioRxiv · Jul 14, 2020 · PreprintImmunology

Method for Zero-Waste Circular Economy using worms for plastic agriculture: Augmenting polystyrene consumption and plant growth

S. K. Gan, S.-X. Phua, J. Y. Yeo, Z. S.-L. Heng, Z. Xing

This study shows mealworms and superworms can consume polystyrene and their frass can support plant growth, offering a zero-waste solution for plastic bioremediation and urban farming.

bioRxiv · May 29, 2020Ecology

The structural basis for distinct binding avidity of Pertuzumab and Trastuzumab IgM towards HER2

F. Samsudin, J. Y. Yeo, S. K.-E. Gan, P. Bond

This paper investigates the structural basis for the differing binding avidity of Pertuzumab and Trastuzumab IgM to HER2, showing that Pertuzumab IgM binds more effectively due to stable engagement via all V-regions.

bioRxiv · Jul 21, 2019 · PreprintImmunology