S. K. Kabra

B cell repertoire sequencing of HIV-1 pediatric elite-neutralizers identifies multiple broadly neutralizing antibody clonotypes

This study identifies multiple broadly neutralizing antibody clonotypes in HIV-1 infected pediatric twins using BCR sequencing, showing ongoing development in one twin but not the other.

Plasma neutralizing antibodies in an infant with interclade HIV-1 superinfection preferentially neutralize superinfecting HIV-1 strains

This study examines nAb responses in an infant with interclade HIV-1 superinfection, finding that neutralizing antibodies primarily target the superinfecting strain and depend on glycans.

A rare mutation in an infant derived HIV-1 envelope glycoprotein alters interprotomer stability and susceptibility to broadly neutralizing antibodies targeting the trimer apex

The paper identifies a rare L184F mutation in HIV-1 Env that destabilizes the trimer apex, leading to escape from broadly neutralizing antibodies targeting the V2 apex.

Broadly neutralizing plasma antibodies effective against diverse autologous circulating viruses in infants with multivariant HIV-1 infection.

The paper identifies viral factors associated with early broadly neutralizing antibody (bnAb) responses in HIV-1-infected infants and suggests implications for polyvalent vaccination strategies.

An HIV-1 broadly neutralizing antibody from a clade C infected pediatric elite neutralizer potently neutralizes the contemporaneous and autologous evolving viruses

This study isolates and characterizes an HIV-1 broadly neutralizing antibody from a pediatric elite neutralizer, showing potent neutralization of cross-clade and autologous viruses.