Author

A. Chandele

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 6 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 7 Organism:human· 6 Research Focus:host-pathogen & immune response· 5 Assay:proteomics· 5 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2

Frequent Co-Authors

E. S. Reddy· 6 shared S. Kumar· 6 shared K. Gottimukkala· 5 shared C. W. Davis· 4 shared K. Murali-Krishna· 4 shared K. Nayak· 4 shared R. Ahmed· 4 shared A. Sharma· 3 shared

Activity by Year

2018-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersImmunology

E. S. Reddy

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response

A. Patel, S. Kumar, L. Lai, C. Chakravarthy, R. Valanparambil, E. S. Reddy, K. Gottimukkala, P. Bajpai, D. R. Raju, V. V. Edara, M. E. Davis-Gardner, S. Linderman, K. Dixit, P. Sharma, G. Mantus, , E. A. Ortlund

The paper identifies three monoclonal antibodies that poorly neutralize the Omicron BA.1 variant, revealing structural and molecular features of antibody evasion.

bioRxiv · Oct 24, 2022Immunology

Transcriptional profiles of functionally distinct HLADR+CD38+ CD8 T cells subsets from acute febrile dengue patients

P. Singh, P. Bajpai, D. Maheshwari, Y. M. Chawla, K. Gottimukkala, E. S. Reddy, K. Saini, K. Nayak, S. Gunisetty, C. Aggarwal, S. Jain, C. Verma, P. Jain, M. Soneja, N. Wig, , A. Chandele

This study identifies transcriptional differences among HLADR+CD38+ CD8 T cell subsets in dengue patients and shows similar expansion patterns across disease severity grades.

bioRxiv · Sep 9, 2022 · PreprintImmunology

Structural insights for neutralization of BA.1 and BA.2 Omicron variants by a broadly neutralizing SARS-CoV-2 antibody

S. Kumar, A. Patel, L. Lai, C. Chakravarthy, R. Valanparambil, M. E. Davis-Gardner, V. V. Edara, S. Linderman, E. S. Reddy, K. Gottimukkala, K. Nayak, P. Bajpai, V. Singh, F. Frank, N. Cheedarla, , A. Chandele

This paper identifies and structurally analyzes an antibody that neutralizes SARS-CoV-2 BA.1 and BA.2 variants, revealing its unique epitope and mechanism of action.

bioRxiv · May 13, 2022Immunology

Dual avatars of E. coli grxB encoded Glutaredoxin 2 perform ascorbate recycling and ion channel activities

S. Nellootil Sreekumar, B. K. Das, R. Raina, N. Puthumadathil, S. Udinia, A. kumar, S. Sahoo, P. Ravichandran, S. Kumar, P. Ray, D. Kumar, A. Chandele, K. R. Mahendran, A. Arockiasamy

This study identifies two functional roles of EcGrx2: ascorbate recycling and ion channel activity, revealing its role in antioxidant defense and membrane integration in E. coli.

bioRxiv · Aug 28, 2021 · PreprintBiochemistry

Immunophenotyping and transcriptional profiling of human plasmablasts in dengue.

C. Aggarwal, K. Saini, E. S. Reddy, M. Singla, K. Nayak, Y. Chawla, D. Maheshwari, P. Singh, P. Sharma, P. Bhatnagar, S. Kumar, K. Gottimukkala, H. Panda, S. Gunisetty, C. W. Davis, , A. Chandele

This study characterizes plasmablasts in dengue patients from India, showing their transcriptional features, adhesion molecule expression, and differential expansion based on infection severity.

bioRxiv · Apr 9, 2021Immunology

Characterization of neutralizing versus binding antibodies and memory B cells in COVID-19 recovered individuals from India

K. Nayak, K. Gottimukkala, S. Kumar, E. S. Reddy, V. V. Edara, R. Kauffman, K. Floyd, G. Mantus, D. Savargaonkar, P. K. Goel, S. Arora, M. Rahi, C. W. Davis, S. Linderman, J. Wrammert, , A. Chandele

This study examines humoral and memory B cell responses in Indian COVID-19 recovered individuals, finding that RBD-specific IgG correlates with neutralizing antibodies and can serve as a surrogate for neutralization assays.

bioRxiv · Aug 31, 2020Immunology

An HIV-1 broadly neutralizing antibody from a clade C infected pediatric elite neutralizer potently neutralizes the contemporaneous and autologous evolving viruses

S. Kumar, H. Panda, M. A. Makhdoomi, N. Mishra, H. A. Safdari, H. Aggarwal, E. S. Reddy, R. Lodha, S. K. Kabra, A. Chandele, S. Dutta, K. Luthra

This study isolates and characterizes an HIV-1 broadly neutralizing antibody from a pediatric elite neutralizer, showing potent neutralization of cross-clade and autologous viruses.

bioRxiv · Aug 29, 2018Immunology