N. Mishra

Computation-aided Design of Rod-Shaped Janus Base Nanopieces for Improved Tissue Penetration and Therapeutics Delivery

This study develops rod-shaped Janus base nanopieces for improved tissue penetration and therapeutics delivery, showing better efficacy than spherical lipid nanoparticles in ovarian cancer models.

Germline-targeting chimpanzee SIV Envelopes induce V2-apex broadly neutralizing-like B cell precursors in a rhesus macaque infection model

This study shows that germline-targeting SCIVs can activate and expand B cells expressing V2-apex bnAb-like precursors in rhesus macaques.

SARS-CoV-2 variants exhibit differential gut tropism and dysbiosis in Syrian golden hamsters.

This study examines SARS-CoV-2 variants' gut tropism and impact on gut microbiota in Syrian golden hamsters, finding Delta's stronger gastrointestinal preference and greater microbial dysbiosis.

Novel Function of Transcription Factor TTF1 in UV Mediated DNA Damage Repair in Mammalian Cells

This study identifies TTF1 as an interactor of DDB1 and shows its role in UV-induced DNA damage repair through co-localization with γH2AX and reciprocal regulation of DDB1 levels.

Broadly neutralizing antibodies targeting a conserved silent face of spike RBD resist extreme SARS-CoV-2 antigenic drift

The paper identifies broadly neutralizing antibodies against SARS-CoV-2 that target conserved regions on the spike RBD, showing resistance to antigenic drift and suggesting potential vaccine targets.

Inferring B-cell derived T-cell receptor induced multi epitope-based vaccine candidate against enterovirus 71 (EV 71): A reverse vaccinology approach.

This study uses reverse vaccinology to design a multi-epitope vaccine against EV71, showing high immunogenicity and safety through computational analysis.

Metabolic plasticity of serine metabolism is crucial for cGAS/STING-signalling and innate immune response to viral infections in the gut

The paper identifies metabolic changes in serine metabolism linked to cGAS/STING-signalling and immune response in gut inflammation.

Oropouche orthobunyavirus infection is mediated by the cellular host factor Lrp1

This study identifies Lrp1 as a host factor required for Oropouche orthobunyavirus infection and suggests a broader role for Lrp1 in bunyavirus entry.

Presence of sodium taurocholate co-transporting polypeptide and Hepatitis B replication marker on placenta: Another home for the virus

The paper investigates NTCP and HBV replication markers in placental cells, finding NTCP expression and viral markers suggesting placental susceptibility to HBV and potential replication.

A high-throughput neutralization assay for yellow fever serodiagnostics

This paper develops a high-throughput fluorescence-based assay (SNTFLUO) for detecting yellow fever neutralizing antibodies, validated against WHO standards and applicable for differential diagnostics.

Semi-supervised sequence modeling for improved behavioral segmentation

This paper introduces a semi-supervised sequence model for behavioral segmentation that combines supervised, weakly supervised, and self-supervised losses to improve accuracy with sparse labels.

Vesicular stomatitis virus chimeras expressing the Oropouche virus glycoproteins elicit protective immune responses in mice.

This paper develops a chimeric VSV expressing OROV glycoproteins that elicits neutralizing antibodies and reduces viral infection in mice.

Microbial regulation of hexokinase 2 links mitochondrial metabolism and cell death in colitis

This study shows that microbial regulation of HK2 links mitochondrial metabolism and cell death in colitis, with butyrate protecting against inflammation by repressing HK2.

Plasma neutralizing antibodies in an infant with interclade HIV-1 superinfection preferentially neutralize superinfecting HIV-1 strains

This study examines nAb responses in an infant with interclade HIV-1 superinfection, finding that neutralizing antibodies primarily target the superinfecting strain and depend on glycans.

Cross-neutralization of SARS-CoV-2 by HIV-1 specific broadly neutralizing antibodies and polyclonal plasma

This study shows that HIV-1 broadly neutralizing antibodies and plasma from HIV-1 infected children can cross-neutralize SARS-CoV-2 by targeting conserved epitopes and glycans on the spike protein.

Deep Graph Pose: a semi-supervised deep graphical model for improved animal pose tracking

This paper introduces a semi-supervised deep graphical model for animal pose tracking that improves accuracy by leveraging spatial and temporal constraints in behavioral videos.

Immunoreactive peptide maps of SARS-CoV-2 and other human coronaviruses

The paper identifies humoral immune responses to SARS-CoV-2 and other human coronaviruses peptides to detect infections and discover immunity biomarkers.

Lung Bronchial Epithelial Cells are HIV Targets for Proviral Genomic Integration

This study shows HIV infects and integrates into lung bronchial epithelial cells, establishing latency and contributing to obstructive lung diseases in HIV-positive individuals.

A rare mutation in an infant derived HIV-1 envelope glycoprotein alters interprotomer stability and susceptibility to broadly neutralizing antibodies targeting the trimer apex

The paper identifies a rare L184F mutation in HIV-1 Env that destabilizes the trimer apex, leading to escape from broadly neutralizing antibodies targeting the V2 apex.

Auto-inhibitory regulation of DNA binding by the C-terminal tails of the mitochondrial transcription factors Mtf1 and TFB2M

This study identifies autoinhibitory mechanisms in Mtf1 and TFB2M where the C-tail region regulates DNA binding activity through intramolecular interactions, which are relieved by RNA polymerase interaction.

Broadly neutralizing plasma antibodies effective against diverse autologous circulating viruses in infants with multivariant HIV-1 infection.

The paper identifies viral factors associated with early broadly neutralizing antibody (bnAb) responses in HIV-1-infected infants and suggests implications for polyvalent vaccination strategies.

Identification of immunoreactive linear epitopes of Borrelia miyamotoi

This study identifies linear epitopes of Borrelia miyamotoi using a peptide array platform to improve serodiagnosis.

A chimeric Japanese encephalitis vaccine protects against lethal yellow fever virus infection without inducing neutralizing antibodies

Viral characteristics associated with sustenance of elite neutralizing activity in chronically HIV-1C infected monozygotic pediatric twins

This study compares viral characteristics in two HIV-1C infected monozygotic twins with differing elite neutralizing antibody profiles, identifying viral mutations associated with neutralization resistance and susceptibility.

An HIV-1 broadly neutralizing antibody from a clade C infected pediatric elite neutralizer potently neutralizes the contemporaneous and autologous evolving viruses

This study isolates and characterizes an HIV-1 broadly neutralizing antibody from a pediatric elite neutralizer, showing potent neutralization of cross-clade and autologous viruses.