S. K. Rai

Single-Molecule FRET Illuminates Structural Subpopulations and Dissects Crucial Molecular Events During Phase Separation of a Prion-Like Low Complexity Domain

The paper uses single-molecule techniques to study phase separation of a prion-like domain, revealing structural subpopulations and molecular events involved in condensate formation and disease-related aggregation.

A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells

This paper introduces an AI-powered nanopore sequencing method to measure DNA replication stress in cancer cells, showing it can distinguish fork slowing from stalling and detect therapy-specific replication stress signatures.

Heterotypic electrostatic interactions control complex phase separation of tau and prion into multiphasic condensates and co-aggregates

This study shows that tau and prion proteins form dynamic condensates through electrostatic interactions, which can transition into solid-like co-aggregates with age.

Spatiotemporal Modulations in Heterotypic Condensates of Prion and α-Synuclein Control Phase Transitions and Amyloid Conversion

This study investigates how prion protein and α-synuclein form dynamic condensates that influence phase transitions and amyloid conversion through electrostatic interactions and RNA effects.

An Intrinsically Disordered Pathological Variant of the Prion Protein Y145Stop Transforms into Self-Templating Amyloids via Liquid-Liquid Phase Separation

This study shows that the Y145Stop variant of the prion protein undergoes liquid-liquid phase separation and transitions into amyloid-like aggregates, highlighting a potential role for intrinsically disordered regions in neurodegenerative diseases.