Author

J. K. Pagan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:long-read sequencing· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Bonfim-Melo· 1 shared B. M. Collins· 1 shared B. Townsend· 1 shared D. C. Ng· 1 shared D. Eldershaw· 1 shared D. Komander· 1 shared G. T. Nguyen-Dien· 1 shared K.-L. Kozul· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. Bonfim-Melo

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4

G. T. Nguyen-Dien, B. Townsend, P. Kulkarni, K.-L. Kozul, S. S. Ooi, D. Eldershaw, S. Weeratunga, M. Liu, M. J. Jones, S. S. Millard, D. C. Ng, M. Pagano, D. Komander, M. Lazarou, B. M. Collins, J. K. Pagan

This study identifies PPTC7 as a cofactor for SCFFBXL4-mediated degradation of BNIP3 and NIX, suppressing mitophagy and revealing a feedback mechanism to regulate mitochondrial homeostasis.

bioRxiv · Feb 23, 2024Cell Biology

A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells

M. J. K. Jones, S. K. Rai, P. L. Pfuderer, A. Bonfim-Melo, J. K. Pagan, P. R. Clarke, S. E. McClelland, M. A. Boemo

This paper introduces an AI-powered nanopore sequencing method to measure DNA replication stress in cancer cells, showing it can distinguish fork slowing from stalling and detect therapy-specific replication stress signatures.

bioRxiv · Sep 22, 2022Cancer Biology