Author

S. K. Sarkar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:protein folding & dynamics· 3 Approach:experimental assay· 2 Approach:microscopy & imaging analysis· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. Klein-Seetharaman· 4 shared L. Kumar· 4 shared C. Harms· 3 shared D. Wright· 3 shared A. Nash· 2 shared S. Kamboj· 2 shared C. Durfee· 1 shared J. Brice· 1 shared

Activity by Year

2017-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersBiophysics

J. Klein-Seetharaman

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Author profile →

5 papers

Recent·Most cited

Quantification of allosteric communications in matrix metalloprotease-1 on alpha-synuclein aggregates and substrate-dependent virtual screening

S. Kamboj, C. Harms, D. Wright, A. Nash, L. Kumar, J. Klein-Seetharaman, S. K. SARKAR

This paper quantifies allosteric communications in MMP1 on alpha-synuclein aggregates using FRET and virtual screening, showing substrate-dependent changes in ligand-binding sites.

bioRxiv · Jan 11, 2021 · PreprintBiophysics

Inter-domain dynamics and fibrinolytic activity of matrix metalloprotease-1

L. Kumar, J. Planas-Iglesias, C. Harms, S. Kamboj, D. Wright, J. Klein-Seetharaman, S. K. Sarkar

This study investigates how inter-domain dynamics of MMP1 correlate with its fibrinolytic activity using single-molecule FRET and kinetic modeling.

bioRxiv · Jul 6, 2020Biophysics

Allosteric communications between domains modulate activity of matrix metalloprotease-1

L. Kumar, A. Nash, C. Harms, J. Planas, D. Wright, J. Klein-Seetharaman, S. K. Sarkar

This paper identifies functionally relevant inter-domain dynamics in MMP1 on collagen fibrils, showing that open conformations correlate with activity and can be modulated by mutations and ligands.

Biophysical Journal · Jul 1, 2020Peer-reviewedBiophysics

Cephalosporins target quorum sensing and suppress virulence of Pseudomonas aeruginosa in Caenorhabditis elegans infection model

L. Kumar, N. Brenner, J. Brice, J. Klein-Seetharaman, S. K. Sarkar

This study shows cephalosporins inhibit quorum sensing and virulence in Pseudomonas aeruginosa, improving survival in C. elegans.

bioRxiv · May 15, 2020 · PreprintMicrobiology

Quantification of cellular distribution as Poisson process in 3D matrix using a multiview light-sheet microscope

W. Colomb, M. Osmond, C. Durfee, M. D. Krebs, S. K. Sarkar

The paper quantifies cellular distribution randomness in a 3D matrix using a multiview light-sheet microscope and Poisson process modeling, showing agreement between simulations and experiments.

bioRxiv · Sep 27, 2017Biophysics