Author

J. Klein-Seetharaman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:differential expression· 1

Frequent Co-Authors

L. Kumar· 4 shared S. K. SARKAR· 4 shared C. Harms· 3 shared D. Wright· 3 shared A. Nash· 2 shared S. Kamboj· 2 shared G. E. Serrano· 1 shared J. Brice· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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4 shared papersBiophysics

L. Kumar

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Low circulating choline, a modifiable dietary factor, is associated with the pathological progression and metabolome dysfunction in Alzheimers disease.

J. M. Judd, P. Jasbi, W. Winslow, G. E. Serrano, J. Klein-Seetharaman, T. Beach, R. Velazquez

The paper investigates the association between low circulating choline and Alzheimer's disease progression, finding it linked to neuropathological features and metabolome dysfunction.

bioRxiv · May 6, 2023Pathology

Quantification of allosteric communications in matrix metalloprotease-1 on alpha-synuclein aggregates and substrate-dependent virtual screening

S. Kamboj, C. Harms, D. Wright, A. Nash, L. Kumar, J. Klein-Seetharaman, S. K. SARKAR

This paper quantifies allosteric communications in MMP1 on alpha-synuclein aggregates using FRET and virtual screening, showing substrate-dependent changes in ligand-binding sites.

bioRxiv · Jan 11, 2021 · PreprintBiophysics

Inter-domain dynamics and fibrinolytic activity of matrix metalloprotease-1

L. Kumar, J. Planas-Iglesias, C. Harms, S. Kamboj, D. Wright, J. Klein-Seetharaman, S. K. Sarkar

This study investigates how inter-domain dynamics of MMP1 correlate with its fibrinolytic activity using single-molecule FRET and kinetic modeling.

bioRxiv · Jul 6, 2020Biophysics

Allosteric communications between domains modulate activity of matrix metalloprotease-1

L. Kumar, A. Nash, C. Harms, J. Planas, D. Wright, J. Klein-Seetharaman, S. K. Sarkar

This paper identifies functionally relevant inter-domain dynamics in MMP1 on collagen fibrils, showing that open conformations correlate with activity and can be modulated by mutations and ligands.

Biophysical Journal · Jul 1, 2020Peer-reviewedBiophysics

Cephalosporins target quorum sensing and suppress virulence of Pseudomonas aeruginosa in Caenorhabditis elegans infection model

L. Kumar, N. Brenner, J. Brice, J. Klein-Seetharaman, S. K. Sarkar

This study shows cephalosporins inhibit quorum sensing and virulence in Pseudomonas aeruginosa, improving survival in C. elegans.

bioRxiv · May 15, 2020 · PreprintMicrobiology