BiochemistrybioRxiv
Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family
X. Guo, A. Söderholm, S. Kanchugal P…·M. Selmer
The paper reveals the structure and mechanism of phage-encoded SAM lyases, showing they function as lyases rather than hydrolases, forming MTA and L-homoserine lactone through a unimolecular reaction.
DOI 10.7554/elife.61818