Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family
X. Guo, A. Söderholm, S. Kanchugal P, G. V. Isaksen, O. Warsi, U. Eckhard, S. Trigüis, A. Gogoll, J. Jerlström-Hultqvist, J. Aqvist, D. Andersson, M. Selmer
The paper reveals the structure and mechanism of phage-encoded SAM lyases, showing they function as lyases rather than hydrolases, forming MTA and L-homoserine lactone through a unimolecular reaction.
bioRxiv · Aug 16, 2020Biochemistry