Role of the Topoisomerase IIα Chromatin Tether domain in Nucleosome Binding & Chromosome Segregation
S. Sundararajan, H. Park, S. Kawano, M. Johansson, T. Saito-Fujita, N. Saitoh, A. Arnaoutov, M. Dasso, D. Clarke, Y. Azuma
This study shows that TopoII's Chromatin Tether domain binds methylated histone H3K27me3 to prevent anaphase ultra-fine bridges, ensuring proper chromosome segregation.
bioRxiv · Oct 3, 2021 · PreprintCell Biology