Author

D. Clarke

Université de Montréal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Neuroscience· 2 Animal Behavior & Cognition· 1 Biochemistry· 1 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:ecology & biodiversity· 2 Approach:statistical model· 2

Frequent Co-Authors

A. Arnaoutov· 1 shared A. Augspach· 1 shared A. E. Marvaldi· 1 shared A. Idris· 1 shared A. Sequeira· 1 shared Alexander D. TangiD· 1 shared B. D. Farrell· 1 shared C. O'Brien· 1 shared

Activity by Year

2018-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperCell Biology

A. Arnaoutov

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8 papers

Recent·Most cited

Chemically induced senescence prompts functional changes in human microglia-like cells

Sandrine Armanville, Chiara Tocco, Zulkhairi Mohamad, D. Clarke, Richard Robitaille, Janelle Drouin‐Ouellet

This study chemically induces senescence in human microglia-like cells and shows they adopt a pro-inflammatory phenotype with reduced phagocytic and calcium activity.

Journal of Immunology Research · Jan 1, 2025Peer-reviewedNeuroscience

The evolutionary history of the ancient weevil family Belidae (Coleoptera: Curculionoidea) reveals the marks of Gondwana breakup and major floristic turnovers, including the rise of angiosperms

X. Li, A. E. Marvaldi, R. G. Oberprieler, D. Clarke, B. D. Farrell, A. Sequeira, M. S. Ferrer, C. O'Brien, S. Salzman, S. Shin, W. Tang, D. D. McKenna

This study reconstructs the evolutionary history of Belidae weevils to show how their host plant shifts and dispersal were influenced by Gondwana breakup and angiosperm rise.

bioRxiv · Mar 12, 2024Evolutionary Biology

Juvenile Atlantic sturgeon survival and movement in proximity to an active cutterhead suction dredge

M. Balazik, D. Clarke

The paper tracks juvenile Atlantic Sturgeon near a dredge and finds no evidence of detrimental impact on survival or movement.

bioRxiv · Mar 1, 2024Animal Behavior & Cognition

Static magnetic stimulation induces structural plasticity at the axon initial segment of inhibitory cortical neurons

Jamie L. Beros, Emma King, D. Clarke, Liz Jaeschke-Angi, Jennifer Rodger, Alexander D. Tang

This study shows that prolonged static magnetic stimulation induces structural changes in the axon initial segment of inhibitory cortical neurons in mice.

Scientific Reports · Jan 17, 2024Peer-reviewedNeuroscience

Minor intron splicing efficiency increases with the development of lethal prostate cancer

A. Augspach, K. Drake, L. Roma, E. Qian, S. R. Lee, D. Clarke, S. Kumar, M. Jaquet, J. Gallon, M. Bolis, J. Triscott, J. A. Galvan, Y. Chen, G. Thalmann, M. Kruithof-de Julio, , M. A. Rubin

The paper shows that minor intron splicing efficiency increases in castration-resistant prostate cancer and that inhibiting the minor spliceosome reduces tumor burden.

bioRxiv · Dec 9, 2021 · PreprintCancer Biology

Role of the Topoisomerase IIα Chromatin Tether domain in Nucleosome Binding & Chromosome Segregation

S. Sundararajan, H. Park, S. Kawano, M. Johansson, T. Saito-Fujita, N. Saitoh, A. Arnaoutov, M. Dasso, D. Clarke, Y. Azuma

This study shows that TopoII's Chromatin Tether domain binds methylated histone H3K27me3 to prevent anaphase ultra-fine bridges, ensuring proper chromosome segregation.

bioRxiv · Oct 3, 2021 · PreprintCell Biology

A Novel Melatonergic Signature Predicts Reccurence Risk and Therapeutic Response in Breast Cancer Patients

M. N. Nguyen, H. Q. Tran, P. L. Luu, V. T. Than, D. Clarke, H. N. Lam, D. T. Nguyen, K. V. T. Le, T. V. Nguyen, M. T. Le, T. X. Hoang, P. Q. Duy, H. T. Tran

The paper identifies an ASMT gene signature that predicts recurrence risk and therapeutic response in breast cancer patients, showing improved outcomes with melatonin and tamoxifen combination therapy.

bioRxiv · Nov 17, 2018Cancer Biology

Development of novel lipidic particles for siRNA delivery that are highly effective after 12 months storage

D. Clarke, A. Idris, N. A. McMillan

This study develops lipidic particles for siRNA delivery that remain effective after 12 months of storage at various temperatures.

bioRxiv · Aug 13, 2018Biochemistry