SCF-FBXW7 regulates G2-M progression through control of CCNL1 ubiquitination
S. O'Brien, S. Kelso, Z. Steinhart, S. Orlicky, M. Mis, Y. Kim, S. Lin, F. Sicheri, S. Angers
This study identifies CCNL1 as a new substrate of SCF-FBXW7 and shows its role in regulating G2-M progression through ubiquitination, revealing a potential therapeutic target in cancer.
bioRxiv · Sep 26, 2022Cancer Biology