Author

Z. Steinhart

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:gene regulatory network inference· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

S. Angers· 3 shared G. Macleod· 2 shared N. Rajakulendran· 2 shared S. Lin· 2 shared A. Marson· 1 shared A. Muraleedharan· 1 shared A. Yang· 1 shared B. Vanderperre· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersCell Biology

S. Angers

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A genome-wide CRISPR/Cas9 screen identifies genes that regulate the cellular uptake of α-synuclein fibrils by modulating heparan sulfate proteoglycans

B. Vanderperre, A. Muraleedharan, M.-F. Dorion, F. Larroquette, E. Del Cid Pellitero, N. Rajakulendran, C. X.- Q. Chen, R. Lariviere, C. Michaud-Tardif, R. Chidiac, D. Lipuma, G. Macleod, R. Thomas, Z. Wang, W. E. Reintsch, , E. A. Fon

This study uses CRISPR/Cas9 screening to identify genes regulating α-synuclein fibril uptake via heparan sulfate proteoglycans, revealing SLC39A9 and C3orf58 as key modulators.

bioRxiv · Sep 29, 2023 · PreprintCell Biology

SCF-FBXW7 regulates G2-M progression through control of CCNL1 ubiquitination

S. O'Brien, S. Kelso, Z. Steinhart, S. Orlicky, M. Mis, Y. Kim, S. Lin, F. Sicheri, S. Angers

This study identifies CCNL1 as a new substrate of SCF-FBXW7 and shows its role in regulating G2-M progression through ubiquitination, revealing a potential therapeutic target in cancer.

bioRxiv · Sep 26, 2022Cancer Biology

CRISPR activation and interference screens in primary human T cells decode cytokine regulation

R. Schmidt, Z. Steinhart, M. Layeghi, J. W. Freimer, V. Q. Nguyen, F. Blaeschke, A. Marson

The paper uses CRISPR activation and interference screens in primary human T cells to identify cytokine regulators, finding genes like FOXQ1 that influence cytokine production and immune cell functions.

bioRxiv · May 11, 2021Immunology

The Mediator tail module cooperates with proneural factors to determine fate identity in Glioblastoma.

M. Ahmadi, G. MacLeod, N. Rajakulendran, M. Kosic, A. Yang, F. Molaei, S. Lin, Z. Steinhart, N. I. Park, P. B. Dirks, S. Angers

The paper identifies MED24 and MED25 as essential for ASCL1-mediated neuronal differentiation in GSCs and other cell types, revealing a role for the Mediator tail module in this process.

bioRxiv · May 4, 2021 · PreprintCell Biology