S. Khetani

Primary Human Hepatocytes Maintain Long-term Functions in Porous Silk Scaffolds Containing Extracellular Matrix Proteins

This study shows that porous silk scaffolds with collagen and fibroblasts support long-term function of primary human hepatocytes, up to 5 months in culture.

Microscale Collagen and Fibroblast Interactions Enhance Primary Human Hepatocyte Functions in 3-Dimensional Models

This study develops 3D collagen microtissues with fibroblast coatings to sustain primary human hepatocyte functions for 6+ weeks, outperforming spheroids and macrogels in hepatic function and drug response.

Intermittent Starvation Extends the Functional Lifetime of Primary Human Hepatocyte Cultures

This study shows that intermittent starvation extends the functional lifespan of primary human hepatocyte cultures, improving drug toxicity testing and metabolic function.