PolyQ expansion does not alter the Huntingtin-HAP40 complex
B. Huang, Q. Guo, M. L. Niedermeier, J. Cheng, T. Engler, M. Maurer, A. Pautsch, W. Baumeister, F. Stengel, S. Kochanek, R. Fernandez-Busnadiego
This study shows that polyQ expansion in HTT does not change the structure of the HTT-HAP40 complex, as revealed by biophysical and cryo-EM analyses.
bioRxiv · Feb 2, 2021Biophysics