F. Stengel

Sbh1/Sec61beta is a specific signal peptide receptor within the Sec61 channel

This study identifies Sbh1/Sec61β as a specific signal peptide receptor that recognizes and guides substrates into the Sec61 channel through its cytosolic IDR and conserved regions.

Kinetic principles of chemical cross-link formation for protein-protein interactions

This study develops a kinetic model to describe cross-link formation in protein-protein interactions and identifies optimal cross-linker concentrations for maximizing cross-link yield.

Small molecule modulation of a redox-sensitive stress granule protein dissolves stress granules with beneficial outcomes for familial amyotrophic lateral sclerosis models

The paper identifies lipoamide as a small molecule that dissolves stress granules and improves outcomes in ALS models by modulating redox-sensitive proteins.

Crosstalk between regulatory elements in the disordered TRPV4 N-terminus modulateslipid-dependent channel activity

The paper investigates how disordered regions in TRPV4 modulate channel activity through lipid-dependent interactions and identifies a conserved autoinhibitory patch that regulates PIP2 binding.

A human RNA ligase that operates via auto- and RNA-AMPylation

This study identifies C12orf29 as a human 5-3 RNA ligase that uses auto- and RNA-AMPylation to catalyze RNA ligation and maintain RNA integrity under stress.

Sequence-directed RNA remodeling within a topologically complex RNP substrate

The paper describes cryo-EM structures of 60S ribosomal intermediates, showing how DEAD-box ATPase Spb4 drives sequence-directed RNA remodeling during RNP assembly.

A mono- and intralink filter (mi-filter) to improve false-discovery rates in cross-linking mass spectrometry data

The paper introduces a filter to reduce false-discovery rates in cross-linking mass spectrometry data by requiring monolink or intra-protein crosslinks for inter-protein link validation.

The interactome of site-specifically acetylated linker histone H1

This study generates site-specifically acetylated H1.2 and identifies its acetylation-dependent interactome, showing distinct interacting partners and involvement of SIRT1.

Structural probing of Hsp26 activation and client binding by quantitative cross-linking mass spectrometry

This study uses cross-linking mass spectrometry to investigate the structural changes and client-binding mechanisms of yeast Hsp26 during activation and refolding.

A comprehensive landscape of 60S ribosome biogenesis factors

The paper maps RBF interactions during 60S ribosome maturation using proteomics and XL-MS, identifying new factors and elucidating their roles.

HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA binding domain

This study identifies HspB8's role in preventing FUS condensate hardening by interacting with its RNA-binding domain, suggesting a mechanism to prevent neurodegenerative disease-associated phase transitions.

PolyQ expansion does not alter the Huntingtin-HAP40 complex

This study shows that polyQ expansion in HTT does not change the structure of the HTT-HAP40 complex, as revealed by biophysical and cryo-EM analyses.