Author

S. Kyheroinen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

M. Sokolova· 3 shared M. K. Vartiainen· 2 shared A. Hyrskyluoto· 1 shared A. Pennanen· 1 shared B. Prajapati· 1 shared E. Sidorenko· 1 shared G. Posern· 1 shared M. Geyer· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCell Biology

M. Sokolova

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3 papers

Recent·Most cited

Actin associates with actively elongating genes and binds directly to the Cdk9 subunit of P-TEFb

S. Kyheroinen, B. Prajapati, M. Sokolova, M. Schmitz, M. Geyer, M. K. Vartiainen

This study identifies a direct interaction between actin and Cdk9 in P-TEFb, showing actin binds to actively elongating genes and inhibits polymerization during transcription.

bioRxiv · Sep 6, 2023Cell Biology

Regulation of nuclear actin levels and MRTF/SRF target gene expression during PC6.3 cell differentiation

S. Kyheroinen, A. Hyrskyluoto, M. Sokolova, M. K. Vartiainen

This study shows that nuclear actin levels increase during PC6.3 cell differentiation, leading to reduced MRTF-A nuclear localization and downregulation of MRTF/SRF target genes.

bioRxiv · Jun 14, 2022Cell Biology

Lamina-associated polypeptide 2α is required for intranuclear MRTF-A activity

E. Sidorenko, M. Sokolova, A. Pennanen, S. Kyheroinen, G. Posern, R. Foisner, M. Vartiainen

This study identifies Lap2 as a novel regulator of MRTF-A activity, showing it is required for efficient expression of MRTF-A/SRF target genes and serum-induced cell migration.

bioRxiv · Jan 8, 2021Cell Biology