Murine Alveolar Macrophages Rapidly Accumulate Intranasally Administered SARS-CoV-2 Spike Protein leading to Neutrophil Recruitment and Damage
C. Park, I.-Y. Hwang, S. L.-S. Yan, S. Vimonpatranon, D. Wei, D. Van Ryk, A. Girard, C. Cicala, J. Arthos, J. H. Kehrl
This study shows that intranasal SARS-CoV-2 Spike protein is rapidly taken up by murine alveolar macrophages, leading to neutrophil recruitment and tissue damage.
bioRxiv · Mar 13, 2023Immunology