J. Kabat

Human ESCRT-I and ALIX function as scaffolding helical filaments in vivo

This study shows ESCRT-I and ALIX form helical filaments in vivo, serving as structural scaffolds and ESCRT-III assembly templates for membrane scission and viral budding.

The neuroimmune CGRP-RAMP1 axis tunes cutaneous adaptive immunity to the microbiota

This study identifies a neuroimmune CGRP-RAMP1 axis that modulates cutaneous adaptive immunity to the microbiota by constraining Type 17 responses and limiting T cell activation.

Chemokine positioning determines mutually exclusive roles for their receptors in extravasation of pathogenic human T cells

This study identifies that chemokine receptors on pathogenic human T cells have mutually exclusive roles in extravasation, with CCR6 mediating arrest and CCR2 enabling transendothelial migration through distinct ligand interactions.

Nuclear translocation of spike mRNA and protein is a novel pathogenic feature of SARS-CoV-2.

This study identifies nuclear translocation of SARS-CoV-2 spike mRNA and protein as a novel pathogenic feature, linked to a unique NLS motif in the spike protein.

CD4 T cells are rapidly depleted from tuberculosis granulomas following acute SIV co-infection

This study shows that acute SIV co-infection rapidly depletes CD4 T cells from tuberculosis granulomas before systemic CD4 T cell loss or disease reactivation.

Histone Variant macroH2A1 Spatially and Functionally Organizes Human Papillomavirus Replication Foci in the Productive Stage of Infection

This study shows macroH2A1 spatially organizes HPV replication foci by separating replication and transcription activities in differentiated cells.

IBEX: A versatile multi-plex optical imaging approach for deep phenotyping and spatial analysis of cells in complex tissues

IBEX enables high-resolution, multi-plex imaging of over 65 parameters in tissue sections without degradation, supporting spatial analysis and integration with other technologies.

Unrestrained Gαi2 Signaling Disrupts Normal Neutrophil Trafficking, Aging, and Clearance

This study shows that disrupting RGS protein-Gi2 interactions in neutrophils leads to impaired trafficking, aging, and clearance, causing inflammation and thrombo-inflammation.

PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques

This study shows that PD-1 blockade worsens Mycobacterium tuberculosis infection in rhesus macaques by increasing bacterial loads and altering immune responses.