Tension anisotropy drives phenotypic transitions of cells via two-way cell-ECM feedback
F. Alisafaei, D. Shakiba, L. Iannucci, M. Davidson, K. Pryse, P.-h. G. Chao, J. Burdick, S. Lake, E. Elson, V. Shenoy, G. Genin
This study shows that tension anisotropy, not stress amplitude, drives phenotypic transitions of fibroblasts to myofibroblasts through cell-ECM feedback.
bioRxiv · Mar 13, 2022 · PreprintBiophysics