Author

F. Alisafaei

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 5 Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Research Focus:development & morphogenesis· 3 Approach:statistical model· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:imaging· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

D. Shakiba· 2 shared E. Elson· 2 shared G. Genin· 2 shared G. M. Genin· 2 shared K. Pryse· 2 shared V. Shenoy· 2 shared X. Peng· 2 shared A. Agashe· 1 shared

Activity by Year

2021-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiophysics

D. Shakiba

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Deep Learning Reveals How Cells Pull, Buckle, and Navigate Tissue-Like Environments

A. Padhi, A. Daw, M. Sawhney, M. M. Talukder, A. Agashe, G. M. Genin, F. Alisafaei, S. Kale, A. Karpatne, A. Nain

This paper introduces DLFM, a deep learning method to measure real-time cell forces in tissue-like environments, revealing new mechanical behaviors during migration and differentiation.

bioRxiv · Oct 24, 2022 · PreprintBiophysics

Matrix Softening Controls Stretch-Induced Cellular Memory and Fibroblast Activation

Y. Hong, X. Peng, H. Yu, M. Jafari, D. Shakiba, Y. Huang, C. Qu, E. Melika, A. Tawadros, A. Mujahid, J. Sandler, K. Pryse, J. Sacks, E. Elson, G. Genin, F. Alisafaei

This study shows that matrix softening influences stretch-induced cellular memory and fibroblast activation, with a model predicting activation levels based on ECM properties.

bioRxiv · Oct 12, 2022 · PreprintBiophysics

Lipid droplets are intracellular mechanical stressors that promote hepatocyte dedifferentiation

A. E. Loneker, F. Alisafaei, A. Kant, P. A. Janmey, V. B. Shenoy, R. G. Wells

This study shows lipid droplets act as intracellular mechanical stressors that cause nuclear deformation and hepatocyte dedifferentiation, similar to tissue stiffening effects.

bioRxiv · Aug 27, 2022 · PreprintCell Biology

Vimentin Intermediate Filaments Can Enhance or Abate Active Cellular Forces in a Microenvironmental Stiffness-Dependent Manner

F. Alisafaei, K. Mandal, M. Swoger, H. Yang, M. Guo, P. Janmey, A. E. Patteson, V. Shenoy

This study shows vimentin intermediate filaments modulate cell-generated forces depending on microenvironment stiffness, increasing forces on stiff matrices and decreasing them on soft matrices.

bioRxiv · Apr 2, 2022 · PreprintBiophysics

Tension anisotropy drives phenotypic transitions of cells via two-way cell-ECM feedback

F. Alisafaei, D. Shakiba, L. Iannucci, M. Davidson, K. Pryse, P.-h. G. Chao, J. Burdick, S. Lake, E. Elson, V. Shenoy, G. Genin

This study shows that tension anisotropy, not stress amplitude, drives phenotypic transitions of fibroblasts to myofibroblasts through cell-ECM feedback.

bioRxiv · Mar 13, 2022 · PreprintBiophysics

An ex vivo culture model of kidney podocyte injury reveals mechanosensitive, synaptopodin-templating, sarcomere-like structures.

J. Shumeng, F. Alisafaei, H. Yuan, X. Peng, Y.-Y. Huang, J. H. Miner, G. M. Genin, H. Y. Suleiman

The paper develops an ex vivo culture model of kidney podocytes to study injury recovery, revealing mechanosensitive sarcomere-like structures that template synaptopodin.

bioRxiv · Nov 3, 2021Cell Biology