Author

S. Lanfredini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:clinical cohort / trial· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1

Frequent Co-Authors

E. O'Neill· 2 shared S. Hughes· 2 shared S. Mukherjee· 2 shared A. Blake· 1 shared A. Burns· 1 shared A. G. Abraham· 1 shared A. Hubert· 1 shared A. Sabbagh· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

E. O'Neill

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Tissue-resident NK cells support survival in pancreatic cancer through promotion of cDC1-CD8T activity

S. Go, C. Demetriou, G. Valenzano, S. Hughes, S. Lanfredini, H. Ferry, E. Arbe-Barnes, S. Sivakumar, R. Bashford-Rogers, M. R. Middleton, S. Mukherjee, J. Morton, K. Jones, E. O'Neill

The paper shows that ionizing radiation enhances immunotherapy in pancreatic cancer by increasing tissue-resident NK cells that support CD8 T cell activity through cDC1-dependent mechanisms.

bioRxiv · Oct 14, 2023Cancer Biology

TET2 drives 5hmc marking of GATA6 and epigenetically defines pancreatic ductal adenocarcinoma transcriptional subtypes

M. Eyres, S. Lanfredini, A. Burns, A. Blake, F. Willenbrock, R. Goldin, D. Hughes, S. Hughes, A. Thapa, D. Valoulis, A. Hubert, Z. D'Costa, A. Sabbagh, A. G. Abraham, C. Blancher, , E. O'Neill

This study identifies TET2-driven 5hmc loss at GATA6 as a mechanism defining PDAC transcriptional subtypes and shows that TET2 stabilization with Metformin and Vitamin C reverses squamous-like tumor features.

bioRxiv · Oct 22, 2020Cancer Biology