S. Hughes

Tissue-resident NK cells support survival in pancreatic cancer through promotion of cDC1-CD8T activity

The paper shows that ionizing radiation enhances immunotherapy in pancreatic cancer by increasing tissue-resident NK cells that support CD8 T cell activity through cDC1-dependent mechanisms.

Optimization for High-Throughput BiFC screening

The paper discusses the Cell-PCA screen's role in analyzing cellular interactomes and identifies areas for optimization to maintain its relevance with advancing biotechnology.

One-Pot Endonucleolytically Exponentiated Rolling Circle Amplification by CRISPR-Cas12a Affords Sensitive, Expedited Isothermal Detection of MicroRNAs

This paper develops a one-pot CRISPR-Cas12a-based assay for sensitive miRNA detection, achieving performance comparable to RT-qPCR while simplifying the workflow.

New insights from short and long reads sequencing to explore cytochrome b variants of Plasmopara viticola populations collected in vineyard and related to resistance to complex III inhibitors

The paper uses short and long-read sequencing to identify cytochrome b variants in Plasmopara viticola populations associated with resistance to fungicides, showing long reads' ability to detect complex variants.

Efficient compartmentalization in insect bacteriomes protects symbiotic bacteria from host immune system

The paper shows that insect bacteriomes protect endosymbionts from host immune responses by confining them physically, preventing direct contact with immune effectors during challenges.

Intestinal GCN2 controls Drosophila systemic growth in response to Lactiplantibacillus plantarum symbiotic cues encoded by r/tRNA operons

The paper shows that Lactiplantibacillus plantarum uses r/tRNA operons to communicate with Drosophila, activating GCN2 in enterocytes to promote systemic growth.

TET2 drives 5hmc marking of GATA6 and epigenetically defines pancreatic ductal adenocarcinoma transcriptional subtypes

This study identifies TET2-driven 5hmc loss at GATA6 as a mechanism defining PDAC transcriptional subtypes and shows that TET2 stabilization with Metformin and Vitamin C reverses squamous-like tumor features.

Bacterial adaptation to diet is a key evolutionary force shaping Drosophila-Lactobacillus symbiosis

This study shows that bacterial adaptation to diet, not the host, drives the evolution of beneficial symbiosis between Drosophila and Lactobacillus.

Stable association of a Drosophila-derived microbiota with its animal partner and the nutritional environment upon transfer between populations and generations

The paper shows that a Drosophila-derived microbiota remains stable when transferred between populations and generations, emphasizing the role of the nutritional substrate in microbiota dynamics.

D-Alanine esterification of teichoic acids contributes to Lactobacillus plantarum mediated intestinal peptidase expression and Drosophila growth promotion upon chronic undernutrition

This study identifies the pbpX2-dlt operon in Lactobacillus plantarum as critical for D-alanine esterification of teichoic acids, which enhances intestinal peptidase expression and promotes Drosophila growth under chronic undernutrition.

Anti-proliferative therapy for HIV cure: a compound interest approach

The paper uses a mathematical model to show that combining anti-proliferative therapies with ART can lead to a functional cure for HIV within 2-10 years instead of decades.