Author

R. Goldin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1

Frequent Co-Authors

W. Alazawi· 2 shared A. Blake· 1 shared A. Burns· 1 shared A. G. Abraham· 1 shared A. Goralcyzk· 1 shared A. Hubert· 1 shared A. Sabbagh· 1 shared A. Schuh· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMolecular Biology

W. Alazawi

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

TLR5 drives metabolic dysfunction-associated steatohepatitis through lipid- and flagellin-induced hepatocyte injury signalling

W. Li, N. Wang, R. Kumar, I. Gines Mir, U. Gill, G. Hood, J. Brindley, C. Mein, J. Boot, R. Wilcox, N. Dufton, R. Goldin, J. Loy, K. Devalia, H. Malik, , W. Alazawi

The paper investigates TLR5's role in MASH and fibrosis using clinical data, single-cell transcriptomics, and in vitro models, finding TLR5 drives hepatocyte injury and fibrosis through flagellin and lipid pathways.

bioRxiv · Feb 7, 2026 · PreprintMolecular Biology

TET2 drives 5hmc marking of GATA6 and epigenetically defines pancreatic ductal adenocarcinoma transcriptional subtypes

M. Eyres, S. Lanfredini, A. Burns, A. Blake, F. Willenbrock, R. Goldin, D. Hughes, S. Hughes, A. Thapa, D. Valoulis, A. Hubert, Z. D'Costa, A. Sabbagh, A. G. Abraham, C. Blancher, , E. O'Neill

This study identifies TET2-driven 5hmc loss at GATA6 as a mechanism defining PDAC transcriptional subtypes and shows that TET2 stabilization with Metformin and Vitamin C reverses squamous-like tumor features.

bioRxiv · Oct 22, 2020Cancer Biology

Stat2 loss disrupts damage signalling and is protective in acute pancreatitis

H. Heath, G. Britton, H. Kudo, G. Renney, M. Ward, R. Hutchins, G. Foster, R. Goldin, W. Alazawi

This study shows that Stat2 deficiency protects against acute pancreatitis by disrupting damage signaling pathways independent of type I interferon, with reduced cytokine levels and NF-κB activation.

bioRxiv · Sep 18, 2019Immunology