Targeted-Antibacterial-Plasmids (TAPs) combining conjugation and CRISPR /Cas systems achieve strain-specific antibacterial activity
A. Reuter, C. Hilpert, A. Dedieu, S. Lematre, E. GUEGUEN, G. Launay, S. Bigot, C. Lesterlin
This paper develops TAPs, plasmids using conjugation and CRISPR/Cas to kill specific bacterial strains, showing they can resensitize resistant bacteria to antibiotics.
bioRxiv · Oct 12, 2020Microbiology