Author

S. Linnarsson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Assay:imaging· 1

Frequent Co-Authors

A. Brech· 1 shared A. Mossi Albiach· 1 shared A. Pfefferle· 1 shared A. Shamikh· 1 shared B. Jacobs· 1 shared C. Grimm· 1 shared C. Mannens· 1 shared D. Clement· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

A. Brech

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Futile wound healing drives mesenchymal-like cell phenotypes in human glioblastoma

A. Mossi Albiach, J. Janusauskas, J. Kjaer Jacobsen, I. Kapustova, R. Karamzadeh, E. Kvedaraite, L. Hu, M. C. Franck, C. Mannens, S. Codeluppi, J. B. Munting, L. E. Borm, A. Shamikh, P. Lonnerberg, K. A. Siletti, , S. Linnarsson

The paper identifies a wound response state in glioblastoma that is shared across malignant and non-malignant cells and is spatially confined to the tumor bulk.

bioRxiv · Sep 1, 2023 · PreprintCancer Biology

Modulation of Secretory Lysosomes During NK Cell Education Leads to Accumulation of Granzyme B and Enhanced Functional Potential

J. P. Goodridge, B. Jacobs, M. L. Satersmoen, D. Clement, T. Clancy, E. Skarpen, A. Brech, J. Landskron, C. Grimm, A. Pfefferle, L. Meza-Zepeda, S. Lorenz, M. T. Wiiger, W. E. Louch, E. H. Ask, , K.-J. Malmberg

This study shows that NK cell education leads to accumulation of granzyme B in secretory lysosomes, enhancing cytotoxic function through lysosomal Ca2+ signaling and TRPML1 regulation.

bioRxiv · Jul 4, 2018Immunology