Multi-omic analysis of the cardiac cellulome defines a vascular contribution to cardiac diastolic dysfunction in obese female mice
M. S. I. Dona, I. Hsu, A. I. Meuth, S. M. Brown, C. A. Bailey, C. G. Aragonez, B. Chandrasekar, L. A. Martinez-Lemus, V. G. DeMarco, L. A. Grisanti, I. Z. Jaffe, A. R. Pinto, S. B. Bender
This study shows that deleting the mineralocorticoid receptor in smooth muscle cells prevents obesity-induced coronary and cardiac diastolic dysfunction in female mice.
bioRxiv · Mar 24, 2022Physiology