Novel bisubstrate inhibitors for protein N-terminal acetyltransferase D
Y. Deng, S. Deng, Y.-H. Ho, S. M. Gardner, Z. Huang, R. Marmorstein, R. Huang
This study designs and characterizes potent bisubstrate inhibitors for NatD, showing high selectivity and revealing the enzyme's ordered Bi-Bi mechanism through crystal structures.
bioRxiv · Jan 24, 2021Biochemistry