Decreased RORC expression and downstream signaling in HTLV-1-associated Adult T-cell Lymphoma/Leukemia uncovers an antiproliferative IL17 link: a potential target for immunotherapy?
K. Subramanian, T. Dierckx, R. Khouri, S. M. Menzes, L. Farre, A. Bittencourt, K. Kataoka, S. Ogawa, J. Van Weyenbergh
The paper identifies decreased RORC expression and downstream antiproliferative IL17 signaling in ATL, suggesting therapeutic potential for boosting RORC/IL17 signaling.
bioRxiv · May 21, 2018Immunology