K. Subramanian

Bacterial pore-forming toxin pneumolysin drives pathogenicity through shed toxin-loaded host extracellular vesicles

This study shows that pneumolysin-loaded host extracellular vesicles contribute to pneumococcal pathogenesis by inducing cytotoxicity and inflammation.

PERK-ATAD3A interaction protects mitochondrial proteins synthesis during ER stress

The paper identifies ATAD3A as a PERK interactor that modulates PERK-eIF2 signaling during ER stress, allowing selective translation of mitochondrial proteins.

An oblique plane microscope for mesoscopic imaging of freely moving organisms with cellular resolution

This paper introduces a mesoscopic oblique plane microscope capable of imaging freely moving organisms at cellular resolution, demonstrating its use on sea anemones.

Metallothionein 3-zinc axis suppresses caspase-11 inflammasome activation and impairs antibacterial immunity

The paper identifies MT3 as a negative regulator of caspase-11 inflammasome activation in macrophages, which suppresses antibacterial immunity.

HSP90 inhibitors reduce cholesterol storage in Niemann-Pick type C1 mutant fibroblasts

This study shows HSP90 inhibitors reduce cholesterol storage in NPC1 mutant fibroblasts by enhancing mutant NPC1 protein delivery to lysosomes.

Proteomic profiling of breast cancer cell lines and models

The paper performs proteomic profiling of 61 breast cancer cell lines, identifies molecular subtypes, and makes datasets publicly available for drug response prediction and therapeutic marker discovery.

Variability in the diet diversity of catfish highlighted through DNA barcoding

This study uses DNA barcoding to analyze the diet diversity of catfish across seasons, revealing seasonal shifts in prey composition and highlighting concerns about their impact on commercial species.

Previously unrecorded distribution of marine sediments derived yeast isolates revealed by DNA barcoding

This study creates a comprehensive DNA barcode library of 1017 marine yeast isolates, revealing 13 new barcoded species and 60% previously unrecorded marine yeast species.

Recapitulating evolutionary divergence in a single regulatory element causes expression changes of the lens gene Tdrd7

The paper investigates how mutations in a regulatory element upstream of Tdrd7 affect lens development by replacing the mouse sequence with the blind mole rat sequence in mice.

Rod nuclear architecture determines contrast transmission of the retina and behavioral sensitivity in mice

This study shows that nuclear inversion in rod cells improves retinal contrast transmission and enhances low-light behavioral sensitivity in mice.

Correction of Niemann-Pick type C1 disease with the histone deacetylase inhibitor valproic acid

This study shows valproic acid corrects the folding and trafficking defect of the I1061T-NPC1 mutation, restoring cholesterol homeostasis and suggesting a potential therapeutic approach for Niemann-Pick type C disease.

EpCAM Aptamer siRNA chimeras: Therapeutic efficacy in epithelial cancer cells.

This study demonstrates that EpCAM aptamer-siRNA chimeras effectively silence oncogenes in epithelial cancers, leading to tumor reduction and apoptosis.

Time resolved quantitative phosphoproteomics reveals distinct patterns of SHP2 dependence in EGFR signaling

The paper uses time-resolved phosphoproteomics to analyze SHP2's role in EGFR signaling, identifying distinct phosphotyrosine response patterns upon SHP099 treatment.

Multi-omics profiling establishes the polypharmacology of FDA Approved CDK4/6 inhibitors and the potential for differential clinical activity

This study compares the mechanisms of three FDA-approved CDK4/6 inhibitors and finds significant differences in their transcriptional, proteomic, and cellular effects, suggesting potential for differential clinical use.

A multi-center study on factors influencing the reproducibility of in vitro drug-response studies

This study investigates factors affecting the reproducibility of in vitro drug-response assays across multiple centers, identifying context-sensitive factors that impact results.

Decreased RORC expression and downstream signaling in HTLV-1-associated Adult T-cell Lymphoma/Leukemia uncovers an antiproliferative IL17 link: a potential target for immunotherapy?

The paper identifies decreased RORC expression and downstream antiproliferative IL17 signaling in ATL, suggesting therapeutic potential for boosting RORC/IL17 signaling.