Cell BiologybioRxivPreprint
Closure motif-mediated state changes of the HORMA protein ASY1
C. Yang, B. Hu, S. M. Portheine…·A. Schnittger
This study shows that PCH2-mediated dissociation of ASY1's HORMA domain from its closure motif is essential for nuclear targeting and chromosomal loading, while the closure motif is also required for PCH2-mediated removal later in prophase.