Author

S. Maddux

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:metagenomics· 3 Organism:mouse· 3 Assay:proteomics· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. Green· 3 shared M. A. Silverman· 3 shared P. J. Planet· 3 shared T. Duranova· 3 shared J.-B. Lubin· 2 shared I. E. Brodsky· 1 shared I. Rozich· 1 shared J. Deschaine· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersImmunology

J. Green

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3 papers

Recent·Most cited

Early-life exposures to specific commensal microbes prevent type 1 diabetes.

J. Green, J. Deschaine, J.-B. Lubin, J. N. Flores, S. Maddux, T. Duranova, L. Grimes, P. J. Planet, L. C. Eisenlohr, M. A. Silverman

A defined consortium of early-life microbes shapes immune development and prevents type 1 diabetes.

bioRxiv · Feb 15, 2024 · PreprintImmunology

Modulation of adaptive immune responses by Akkermansia muciniphila is restricted to an early life window in NOD mice

S. Maddux, J.-B. A. Lubin, J. Green, J. Flores, I. Rozich, T. Duranova, P. J. Planet, M. A. Silverman

This study shows Akkermansia muciniphila induces regulatory T cells and enhances antibody responses in NOD mice only when exposed before weaning, highlighting a critical early-life window for immune modulation.

bioRxiv · Aug 16, 2022 · PreprintImmunology

Arresting microbiome development limits immune system maturation and resistance to infection.

J.-B. Lubin, J. Green, S. Maddux, L. Denu, T. Duranova, M. Lanza, M. Wynosky-Dolfi, I. E. Brodsky, P. J. Planet, M. A. Silverman

This study shows that delaying microbiome development during weaning impairs immune system maturation and increases susceptibility to infection.

bioRxiv · Jan 17, 2022 · PreprintImmunology