Modulation of adaptive immune responses by Akkermansia muciniphila is restricted to an early life window in NOD mice
S. Maddux, J.-B. A. Lubin, J. Green, J. Flores, I. Rozich, T. Duranova, P. J. Planet, M. A. Silverman
This study shows Akkermansia muciniphila induces regulatory T cells and enhances antibody responses in NOD mice only when exposed before weaning, highlighting a critical early-life window for immune modulation.
bioRxiv · Aug 16, 2022 · PreprintImmunology