Author

S. Morganella

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1 Assay:whole-exome sequencing· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

A. B. Brinkman· 1 shared A. Boot· 1 shared A. Butler· 1 shared A. Ferrari· 1 shared A. L. Richardson· 1 shared A. Sieuwerts· 1 shared A. W. T. Ng· 1 shared A.-L. Borresen-Dale· 1 shared

Activity by Year

2018-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. B. Brinkman

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2 papers

Recent·Most cited

The Repertoire of Mutational Signatures in Human Cancer

L. Alexandrov, J. Kim, N. J. Haradhvala, M. N. Huang, A. W. T. Ng, Y. Wu, A. Boot, K. R. Covington, D. A. Gordenin, E. Bergstrom, S. M. A. Islam, N. Lopez-Bigas, L. J. Klimczak, J. R. McPherson, S. Morganella, , M. R. Stratton

The paper characterizes 49 mutational signatures in human cancer using a large dataset of somatic mutations, revealing associations with exposures and DNA repair mechanisms and identifying signatures of unknown origin.

bioRxiv · Jul 3, 2019Cancer Biology

Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation

A. B. Brinkman, S. Nik-Zainal, F. Simmer, F. G. Rodriguez-Gonzalez, M. Smid, L. B. Alexandrov, A. Butler, S. Martin, H. Davies, G. Dominik, X. Zou, M. Ramakrishna, J. Staaf, M. Ringner, A. Sieuwerts, , H. G. Stunnenberg

The paper shows PMDs are hypervariable in breast cancer and drive CGI hypermethylation, but do not significantly repress cancer genes.

bioRxiv · Nov 15, 2018Cancer Biology